Jerusalem. — Iran launched waves of missiles that hit Haifa, in northern Israel, and Jerusalem, while the Israelis attacked refineries and military installations. At least four people were reported dead in the Hebrew state, while Iran accused Israel of precipitating the Middle East into a “dangerous cycle of violence” and undermining talks between Tehran and Washington on the Islamic Republic’s nuclear program.

The attacks mark the latest salvo since a surprise Israeli assault two days earlier aimed at crippling Tehran's rapidly advancing nuclear program. Fresh explosions rang out in Tehran as Iranian missiles pierced Israeli skies in an attack that Israeli emergency officials said killed four people at an apartment building in the Galilee. No casualty figures were immediately available in Iran, where Israel targeted the Defense Ministry headquarters in Tehran as well as sites believed to be linked to the country's nuclear program.

Amid the ongoing conflict, planned negotiations between Iran and the United States over Tehran's nuclear program were canceled, casting doubt on when—and how—an end to the fighting might come.

“Tehran is burning,” Israeli Defense Minister Israel Katz said on social media, and Iranian state television said explosions were heard in the east and west of the city.

Both the Israeli military and Iranian state TV announced the latest round of Iranian missile fire after explosions were heard around midnight as Israel's security cabinet was meeting. Iran's paramilitary Revolutionary Guard said in a statement that the Iranian missiles hit facilities producing fuel for Israeli warplanes. It added that Iran would fire more missiles if the Israeli attacks continued.

The Magen David Adom emergency service reported that one woman was killed and more than a dozen others were injured when a two-story house in the north was attacked. Within an hour, the Israeli army announced that people could leave the shelters.

Israel's continued attacks across Iran have left the country's surviving leaders with the difficult decision of whether to plunge deeper into conflict with Israel's more powerful forces or seek a diplomatic path.

World leaders issued urgent calls to de-escalate tensions and avoid all-out war. The attack on the nuclear facilities set a “dangerous precedent,” China’s foreign minister declared.

The sixth round of indirect talks between the United States and Iran, scheduled for Sunday, on Iran's nuclear program, will not take place, mediator Oman said.

Israeli Prime Minister Benjamin Netanyahu said Saturday that the Israeli military will bomb “all regime sites” in Iran, adding that the Israeli strikes dealt a “real blow to the Islamic Republic’s nuclear program.” “We will hit all the sites and targets of the ayatollahs’ regime,” Netanyahu said.

Iran's top diplomat declared on Saturday that nuclear talks were"unjustifiable" following the Israeli attacks. Abbas Araghchi made the comments during a call with Kaja Kallas, the European Union's top diplomat.

Trump, in agreement with Putin

US President Donald Trump said Saturday that he and Russian President Vladimir Putin agreed in a phone call that the war between Iran and Israel “must end.” “President Putin called me this morning to very graciously wish me a happy birthday,” said Trump, who turned 79. “He and I believe that this war between Israel and Iran must end, and as I explained, their war must end as well.” Agencies